Polymorphic Selectivity in Crystal Nucleation. Kinetics of Surface Enrichment of a Polymer in a Glass-Forming Molecular Liquid. Issue “Crystallizing the Role of Solid-State Form in Drug Delivery”. Effect of Surfactants on Crystal Nucleation and Growth of Amorphous Nifedipine. Solvent-mediated Polymorphic Transformations in Molten Polymers: The Account of Acetaminophen. Hernández Espinell, José Toro, Veronica Yao, Xi Yu, Lia López-Mejías, Vilmalí Stelzer, Torsten. Anisotropic Molecular Organization at a Liquid/Vapor Interface Promotes Crystal Nucleation with Polymorph Selection. Influence of moisture and surfactants on surface dynamics of amorphous drugs: A concentration-temperature superposition principle. Surface Enhancement of Crystal Nucleation in Amorphous Acetaminophen. ROY: Using the Method of Molecular Voronoi−Dirichlet Polyhedra to Examine the Fine Features of Conformational Polymorphism. Surface-enhanced crystal nucleation and polymorph selection in amorphous posaconazole. Amorphous Drug-Polymer Salts: Maximizing proton transfer to enhance stability and release. We are developing amorphous pharmaceuticals that are stable in hot and humid environments for global health applications. We study the stability of glasses against crystallization, the role of surface mobility in glass crystallization and manufacturing, and the ability to create glasses with tunable liquid-crystalline order. Glasses are remarkable materials with solid-like strength and liquid-like uniformity with applications in pharmaceutics, electronics, and bio-preservation. Some questions being investigated include: Why do some molecules have many polymorphs and others seemingly none? Why do polymorphs nucleate and grow from the same liquid at very different rates? How does a liquid/vapor interface influence crystallization and polymorph selection? Polymorphism is the ability of the same molecule to crystallize in different structures and an important phenomenon for all crystalline materials because polymorphs have different properties. They exhibit physical phenomena unknown for hard materials and offer new opportunities for materials engineering. These materials contain complex molecules assembled by many types of intermolecular forces. Member FDIC.We study the solid materials of organic molecules important for pharmaceutical formulations and electronic devices. Bank of England Mortgage is not affiliated with any government agency. This contact information is for accommodation requests only.īank of England Mortgage is an equal opportunity employer and encourages women, minorities, persons with disabilities, and veterans to apply.īank of England Mortgage is a division of Bank of England. If you are an individual with disabilities who needs accommodation, or you are having difficulty using our website to apply for a loan, please contact us at (913) 210-8514. You should verify all information before relying on it and decisions based on information contained in our site are your sole responsibility. The information published on this site is provided as a convenience to visitors and is for informational purposes only. Bank of England Mortgage may change the products, services, and any other information described on this site at any time. From time to time changes may be made to the content of this site without notice. Bank of England Mortgage has tried to provide accurate and timely information however, the content of this site may not be accurate, complete or current and may include technical inaccuracies or typographical errors.
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